DNA DAMAGE | types

DNA DAMAGE | types

DNA DAMAGE

Drug-or radiation-triggered changes in DNA that introduce deviations from its regular double-helical conformation. These changes encompass structural distortions which can problem with replication and transcription and point mutations which mutate base pairs and exert damaging effects on future generations through changes in DNA sequence .DNA damage does not always bring about in mutagenesis.

HOW THE DAMAGE CHANGE DNA STRUCTURE

• Breakage of the strand
• Changes to bases
• Damage of sugars
• Dimer formation and crosslinking

TYPES OF DAMAGE

1.Single base alteration

• Depurination
• Deamination
• Alkylation
• Base analogue incorporation

2. Double base alteration

• Pyrimidine dimer
• Purine dimer

3.Chain break

• Single stranded break
• Double stranded break

4.Cross linking

• DNA to protein
• DNA to DNA